The Sr. Principal Scientist will lead and oversee a team of 15-30 process and analytical chemists in developing phase-appropriate processes and analytical methods for Pfizer's Drug-Linker portfolio. Responsibilities include ensuring project delivery, improving lab capabilities, documentation of experimental work, and fostering collaboration with internal and external partners.
- State of the art knowledge of process chemistry, analytical chemistry, scale-up, modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis, and physical organic chemistry as it relates to reaction mechanism is expected.
- Contemporary knowledge of drug development, the pharmaceutical industry, and fundamental principles of process development from a laboratory and manufacturing perspective.
- Strong track record of managing integrated synthetic chemistry development laboratories with 15-30 process chemists and analytical chemists.
- Strong track record of successful delivery of projects, using sound scientific analysis and judgment to advance programs.
- Good interpersonal skills
- Experience of leading and developing teams, mentoring and directing other colleagues.
- Excellent oral and written communication skills, including the ability to maintain an accurate scientific notebook, and draft concise emails, written reports, publications, synthesis information packages and related documents
- Rational, innovative and creative approach to problem solving.
- Capable of leading and planning the scientific direction of multi-discipline projects.
- Job location: Onsite, Chennai
- Lead a group of 15-30 process and analytical chemists at an external partner located in India to deliver phase-appropriate processes, analytical methods and vendor synthetic information packages (VSIPs) for Pfizer's Drug-Linker portfolio.
- Work with Pfizer and external partner's EHSS groups to develop and implement best practices for the synthesis, purification and handling of low OEL compounds.
- Use extensive technical knowledge and experience in state-of-the-art organic and process chemistry to personally deliver and lead others in the development of safe, sustainable, robust, cost-efficient and phase-appropriate process that are aligned with internal business needs.
- Develop, refine, and maintain productivity metrics of FTEs for resource allocation discussions with key internal stakeholders.
- Develop strategic plans to drive improvement in lab capabilities (process chemistry and analytical chemistry) and enhance productivity.
- Develop secure and robust data sharing infrastructure between Pfizer and external partners in collaboration with IT and functional areas
- Set up business workflows to streamline material shipment and logistics
- Build a safe, inclusive, and innovative culture within the chemistry labs.
- Work collaboratively and effectively, building and leading high performing teams
- Ensure accurate and timely documentation of experimental work, and clear and concise presentation of work to stakeholders both internally and externally.
- Develop a strong relationship with external partner management, with open and effective communication and active listening (inc. sharing of plans, co-ordination of resources, alignment of priorities).
- Build a strong interface and network with Pfizer's Chemical Process and Analytical Development group (Global Chemical Research and Development) and keep up to date with synthetic and technology advancements.
- Look for opportunities to align, share and implement best practices across sites.
- Master's degree in Chemistry, Chemical Engineering or a related field and 15+ years of experience in process chemistry research and development towards New Chemical Entities (APIs) or fine chemicals
or
- PhD in Organic Chemistry, API, Chemical synthesis or a related field with 8+ years of experience in process chemistry research and development towards New Chemical Entities (APIs) or fine chemicals
- Experience in leading cross-functional teams is a plus.
Work Location : Onsite, Chennai Pfizer Site
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
Research and Development
#LI-PFE
Top Skills
Analytical Chemistry
Organic Chemistry
Process Chemistry
Synthetic Chemistry
Similar Jobs at Pfizer
Be an Early Applicant
As a Senior Scientist at Pfizer, you will design and develop drug formulations, leveraging scientific knowledge to enhance drug delivery and performance. Your role includes mentoring team members, collaborating on multidisciplinary projects, and authoring regulatory submissions. You'll utilize technical expertise to solve project challenges and ensure quality outcomes to support the development of novel medicines.
Be an Early Applicant
The Principle Scientist will lead a team of chemists, focusing on organic and process chemistry for drug linkers. The role involves strategic planning, developing purification processes, and ensuring effective collaboration across departments to achieve project goals. The candidate will leverage extensive technical knowledge to drive projects that meet internal and external requirements while maintaining high scientific standards.
Be an Early Applicant
The Senior Associate Scientist is responsible for analytical method development, validation, and regulatory support for various drug formulations. This role involves conducting stability studies, troubleshooting analytical methods, and ensuring compliance with quality and safety standards. Collaboration with cross-functional teams for timely project delivery is also essential.
What you need to know about the Hyderabad Tech Scene
Because of its proximity to leading research institutions and a government committed to the city's growth, Hyderabad's tech scene is booming. With plans to establish India's first "AI city," the city is on track to become one of the world's most anticipated tech hubs, with companies like TransUnion, Schrödinger and Freshworks, among others, already calling the city home.
