The Principle Scientist will lead a team of chemists, focusing on organic and process chemistry for drug linkers. The role involves strategic planning, developing purification processes, and ensuring effective collaboration across departments to achieve project goals. The candidate will leverage extensive technical knowledge to drive projects that meet internal and external requirements while maintaining high scientific standards.
- State of the art knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis, and physical organic chemistry as it relates to reaction mechanism is expected.
- Contemporary knowledge of drug development, the pharmaceutical industry, and fundamental principles of process development from a laboratory and manufacturing perspective.
- Strong track record of successful delivery of projects, using sound scientific analysis and judgment to advance programs
- Good interpersonal skills
- Experience of leading small teams of 5-8 chemists, mentoring and directing other colleagues.
- Excellent oral and written communication skills, including the ability to maintain an accurate scientific notebook, and draft concise emails, written reports, publications, synthesis information packages and related documents
- Rational, innovative and creative approach to problem solving.
- Job location: Onsite, Chennai
- Lead a group of 5-8 process chemists at an external partner located in India to deliver phase-appropriates processes and vendor synthetic information packages (VSIPs) for Pfizer's Drug-Linker portfolio.
- Use extensive technical knowledge and experience in state-of-the-art organic and process chemistry to develop safe, sustainable, robust, cost-efficient, and phase-appropriate process that are aligned with internal business needs.
- Develop strategic plan to develop and implement purification and separation capabilities at the external partner that is driven by drug linkers portfolio needs with internal stakeholders.
- Work collaboratively and effectively, building and leading high performing teams
- Ensure accurate and timely documentation of experimental work, and clear and concise presentation of work to stakeholders both internally and externally.
- Co-ordinate work with other functions (Process safety, engineering, analytical)/ departments to achieve project objectives.
- Build a strong interface and network with Pfizer's Chemical Process and Analytical Development group (Global Chemical Research and Development) and keep up to date with synthetic and technology advancements.
- Support in designing and refining workflows and metrics.
- Look for opportunities to align, share and implement best practices.
- Contribute to the development of a strong scientific, process chemistry, safety and quality culture within the chemistry labs.
- Master's degree in Chemistry, Chemical Engineering or a related field and 10+ years of experience in process chemistry research and development towards New Chemical Entities (APIs) or fine chemicals
- or
- PhD in Organic Chemistry or a related field with 6+ years of experience in process chemistry research and development towards New Chemical Entities (APIs) or fine chemicals
- Develop state of the art purification strategies and capabilities for complex synthetic molecules such as Drug-Linkers.
- Plan the scientific direction of projects by providing high quality experimental planning, evaluation and characterization of chromatography purification and synthetic processes.
Work Location: Onsite, Pfizer Chennai
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
Research and Development
#LI-PFE
Top Skills
Asymmetric Synthesis
Catalysis
Drug Development
Green Chemistry
Organic Chemistry
Physical Organic Chemistry
Process Development
Synthetic Methodology
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